The Vyas Laboratory studies the intersection between pathogenic fungal organisms and initial host responses. Invasive fungal infections are a leading cause of death among immunocompromised patients. It is therefore essential to define the cellular and molecular mechanisms of host-pathogen interactions to improve outcomes for patients with invasive fungal infections. Using animal models, cell culture systems, and patient samples, the NIH-funded Vyas Laboratory investigates the mechanisms involved in responses to fungi in lung and bloodstream fungal infections to reveal novel therapeutic targets for high-risk patients.

The laboratory is located in the Division of Infectious Diseases, Department of Medicine at the Vagelos College of Physicians and Surgeons at Columbia University.