Matthaiou EI, El-Hafeez AAA, Sharifi H, Chatterjee P, Zinter M, Johansson P, Dhillon E, Chiu W, Qian J, Shaller B, Chang J, Pasupneti S, Borges CH, Omar S, Enejder A, Dhillon G, Gaudilliere B, Fortwendel J, Vyas JM, Hsu JL. Macrophage ferroptosis inhibits Aspergillus conidial killing in lung transplantation. bioRxiv [Preprint]. 2025 Mar 15:2025.03.13.643092. PMID: 40161807.
Kwaku GN, Jensen KN, Simaku P, Floyd DJ, Saelens JW, Reardon CM, Ward RA, Basham KJ, Hepworth OW, Vyas TD, Zamith-Miranda D, Nosanchuk JD, Vyas JM, Harding HB. Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation. bioRxiv [Preprint]. 2025 Jan 3:2025.01.03.631181. PMID: 39803513.
Harding AT, Crossen AJ, Reedy JL, Basham KJ, Hepworth OW, Zhang Y, Shah VS, Harding HB, Surve MV, Simaku P, Kwaku GN, Jensen KN, Otto Y, Ward RA, Thompson GR, Klein BS, Rajagopal J, Sen P, Haber AL, Vyas JM. Single-cell analysis of human airway epithelium identifies cell type-specific responses to Aspergillus and Coccidioides. bioRxiv [Preprint]. 2024 Sep 13:2024.09.09.612147. PMID: 39314271.
Selected Publications
Xu S, Tan S, Romanos P, Reedy JL, Zhang Y, Mansour MK, Vyas JM, Mecsas J, Mou H, Leong JM. Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia. mBio. 2024 Aug 9:e0185624. PMID: 39120139.
Reedy JL, Jensen KN, Crossen AJ, Basham KJ, Ward RA, Reardon CM, Brown Harding H, Hepworth OW, Simaku P, Kwaku GN, Tone K, Willment JA, Reid DM, Stappers MHT, Brown GD, Rajagopal J, Vyas JM. Fungal melanin suppresses airway epithelial chemokine secretion through blockade of calcium fluxing. Nat Commun. 2024 Jul 10;15(1):5817. PMID: 38987270.
Kwaku GN, Ward RA, Vyas JM, Brown Harding H. Host Innate Immune Systems Gather Intel on Invading Microbes Via Pathogen-Derived Extracellular Vesicles. Extracellular Vesicle. 2024 June; 3:100043. doi.org/10.1016/j.vesic.2024.100043
Vargas-Blanco DA, Hepworth OW, Basham KJ, Simaku P, Crossen AJ, Timmer KD, Hopke A, Brown Harding H, Vandal SR, Jensen KN, Floyd DJ, Reedy JL, Reardon C, Mansour MK, Ward RA, Irimia D, Abramson JS, Vyas JM. BTK Inhibitor-Induced Defects in Human Neutrophil Effector Activity Against Aspergillus fumigatus Are Restored by TNFα. JCI Insight. 2024 May 7:e176162. PMID: 38713531.
Brandt M, Cao Z, Krishna C, Reedy JL, Gu X, Dutko RA, Oliver BA, Tusi BK, Park J, Richey L, Segerstolpe Å, Litwiler S, Creasey EA, Carey KL, Vyas JM, Graham DB, Xavier RJ. Translational Genetics Identifies a Phosphorylation Switch in CARD9 Required for Innate Inflammatory Responses. Cell Rep. 2024 Mar 26;43(3):113944. PMID: 38489265.
Brown Harding H, Kwaku GN, Reardon CM, Khan NS, Zamith-Miranda D, Zarnowski R, Tam JM, Bohaen CK, Richey L, Mosallanejad K, Crossen AJ, Reedy JL, Ward RA, Vargas-Blanco DA, Basham KJ, Bhattacharyya RP, Nett JE, Mansour MK, van de Veerdonk FL, Kumar V, Kagan JC, Andes DR, Nosanchuk JD, Vyas JM. Candida albicans Extracellular Vesicles Trigger Type I IFN Signaling via cGAS and STING. Nat Microbiol. 2024 Jan 24;16(731):eadk1599. PMID: 38266109.
Surve MV, Lin B, Reedy JL, Crossen AJ, Xu A, Klein BS, Vyas JM, Rajagopal J. Single Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells. Am J Respir Cell Mol Biol. 2023 Dec;69(6):698-701. PMID: 38038398.
Datta A, Das D, Nett JE, Vyas JM, Lionakis MS, Thangamani S. Differential Skin Immune Responses in Mice Intradermally Infected with Candida auris and Candida albicans. Microbiol Spectr. 2023 Oct 9:e0221523. PMID: 37811989.
Galgiani JN, Hsu AP, Powell DA, Vyas JM, Holland SM. Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician's Perspective. J Fungi (Basel). 2023 May 11;9(5):554. PMID: 37233265.
Crossen AJ, Ward RA, Reedy JL, Surve MV, Klein BS, Rajagopal J, Vyas JM. Human Airway Epithelium Responses to Invasive Fungal Infections: A Critical Partner in Innate Immunity. J Fungi (Basel). 2022 Dec 27;9(1):40. PMID: 36675861.
Zhang Y, Lin T, Leung HM, Zhang C, Wilson-Mifsud B, Feldman MB, Puel A, Lanternier F, Couderc LJ, Danion F, Catherinot E, Salvator H, Tcherkian C, Givel C, Xu J, Tearney GJ, Vyas JM, Li H, Hurley BP, Mou H. STAT3 Mutation-Associated Airway Epithelial Defects in Job Syndrome. J Allergy Clin Immunol. 2023 Jan 10:S0091-6749(23)00007-6. PMID: 36638921.
Reedy JL, Crossen AJ, Negoro PE, Harding HB, Ward RA, Vargas-Blanco DA, Timmer KD, Reardon CM, Basham KJ, Mansour MK, Wüthrich M, Fontaine T, Latgé JP, Vyas JM. The C-Type Lectin Receptor Dectin-2 Is a Receptor for Aspergillus fumigatus Galactomannan. mBio. 2023 Jan 4:e0318422. PMID: 36598192.
Ward RA, Aghaeepour N, Bhattacharyya RP, Clish CB, Gaudillière B, Hacohen N, Mansour MK, Mudd PA, Pasupneti S, Presti RM, Rhee EP, Sen P, Spec A, Tam JM, Villani AC, Woolley AE, Hsu JL, Vyas JM. Harnessing the Potential of Multiomics Studies for Precision Medicine in Infectious Disease. Open Forum Infect Dis. 2021 Sep 25;8(11):ofab483. PMID: 34805429.
Ward RA, Thompson GR 3rd, Villani AC, Li B, Mansour MK, Wuethrich M, Tam JM, Klein BS, Vyas JM. The Known Unknowns of the Immune Response to Coccidioides. J Fungi (Basel). 2021 May 11;7(5):377. PMID: 34065016.
Wiesner DL, Merkhofer RM, Ober C, Kujoth GC, Niu M, Keller NP, Gern JE, Brockman-Schneider RA, Evans MD, Jackson DJ, Warner T, Jarjour NN, Esnault SJ, Feldman MB, Freeman M, Mou H, Vyas JM, Klein BS. Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe. 2020 Apr 8;27(4):614-628.e6. PMID: 32130954.
Feldman MB, Dutko RA, Wood MA, Ward RA, Leung HM, Snow RF, De La Flor DJ, Yonker LM, Reedy JL, Tearney GJ, Mou H, Hurley BP, Vyas JM. Aspergillus fumigatus Cell Wall Promotes Apical Airway Epithelial Recruitment of Human Neutrophils. Infect Immun. 2020 Jan 22;88(2):e00813-19. PMID: 31767773.
Khan NS, Lukason DP, Feliu M, Ward RA, Lord AK, Reedy JL, Ramirez-Ortiz ZG, Tam JM, Kasperkovitz PV, Negoro PE, Vyas TD, Xu S, Brinkmann MM, Acharaya M, Artavanis-Tsakonas K, Frickel EM, Becker CE, Dagher Z, Kim YM, Latz E, Ploegh HL, Mansour MK, Miranti CK, Levitz SM, Vyas JM. CD82 Controls CpG-Dependent TLR9 Signaling. FASEB J. 2019 Nov;33(11):12500-12514. PMID: 31408613.
Jones CN, Ellett F, Robertson AL, Forrest KM, Judice K, Balkovec JM, Springer M, Markmann JF, Vyas JM, Warren HS, Irimia D. Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro. Front Immunol. 2019 Apr 9;10:644. PMID: 31024528.
Tam JM, Reedy JL, Lukason DP, Kuna SG, Acharya M, Khan NS, Negoro PE, Xu S, Ward RA, Feldman MB, Dutko RA, Jeffery JB, Sokolovska A, Wivagg CN, Lassen KG, Le Naour F, Matzaraki V, Garner EC, Xavier RJ, Kumar V, van de Veerdonk FL, Netea MG, Miranti CK, Mansour MK, Vyas JM. Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans. J Immunol. 2019 Jun 1;202(11):3256-3266. PMID: 31010852.
Li SS, Ogbomo H, Mansour MK, Xiang RF, Szabo L, Munro F, Mukherjee P, Mariuzza RA, Amrein M, Vyas JM, Robbins SM, Mody CH. Identification of the Fungal Ligand Triggering Cytotoxic PRR-Mediated NK Cell Killing of Cryptococcus and Candida. Nat Commun. 2018 Feb 21;9(1):751. PMID: 29467448.
Khan NS, Kasperkovitz PV, Timmons AK, Mansour MK, Tam JM, Seward MW, Reedy JL, Puranam S, Feliu M, Vyas JM. Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing β-1,3 Glucan. J Immunol. 2016 Mar 1;196(5):2249-61. PMID: 26829985.
Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM. Dectin-1-Dependent LC3 Recruitment to Phagosomes Enhances Fungicidal Activity in Macrophages. J Infect Dis. 2014 Dec 1;210(11):1844-54. PMID: 24842831.
